switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P23458 (1 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_SH2_IE	EGFR_HUMAN	1008	1024	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK1 (JAK1) protein.	details	Inferred