Type: Pre‑assembly Subtype: Composite binding site formation |
The formation of a complex results in the generation of a continuous motif-binding site that spans more than one component of this complex. Neither complex subunit on its own contains a functional binding domain for the motif, and interaction of the motif only occurs in the context of the active, fully assembled complex.
|
| FINC_HUMAN | LIG_RGD | 1524 | 1526 | Binding of Fibronectin (FN1) to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | details |
| FINC_HUMAN | LIG_Integrin_isoDGR_1 | 263 | 265 | Binding of Fibronectin (FN1) to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | details |
