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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:Q93009 (2 hits) x


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          Curated          inferred


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NP_000042 (?)Serine-protein kinase ATM


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

NP_000042 - ? -  ?
DOC_USP7_1 MDM4_HUMAN398402BinaryPhysicochemical compatibilityPhosphorylation of S403 adjacent to the USP7-binding motif of Protein Mdm4 (MDM4) by Serine-protein kinase ATM (ATM) inhibits binding to the Ubiquitin carboxyl-terminal hydrolase 7 (USP7), thereby reducing deubiquitylation of Protein Mdm4 (MDM4). As a result, ubiquitylation by E3 ubiquitin-protein ligase Mdm2 (MDM2) is not countered and Protein Mdm4 (MDM4) is targeted for proteasomal degradation.
details
Inferred

Serine-protein kinase ATM - ATM -  Homo sapiens
DOC_USP7_1 MDM4_HUMAN398402BinaryPhysicochemical compatibilityPhosphorylation of S403 adjacent to the USP7-binding motif of Protein Mdm4 (MDM4) by Serine-protein kinase ATM (ATM) inhibits binding to the Ubiquitin carboxyl-terminal hydrolase 7 (USP7), thereby reducing deubiquitylation of Protein Mdm4 (MDM4). As a result, ubiquitylation by E3 ubiquitin-protein ligase Mdm2 (MDM2) is not countered and Protein Mdm4 (MDM4) is targeted for proteasomal degradation.
details
Curated
           
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