switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: UNIPROT:P04049 (2 hits) x

x Coloured by: Pathway evidence source
Curated inferred

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Information

Evidence

PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_14-3-3_1	RAF1_HUMAN	256	261	Avidity‑sensing	Phosphorylation of two 14-3-3-binding motifs in RAF proto-oncogene serine/threonine-protein kinase (RAF1) in response to growth factors induces high-avidity binding to dimeric 14-3-3 protein zeta/delta (YWHAZ), with pS621 being the high-affinity interaction site. This interaction locks RAF proto-oncogene serine/threonine-protein kinase (RAF1) in an inhibited conformation.	details	Curated
LIG_14-3-3_1	RAF1_HUMAN	618	623	Avidity‑sensing	Phosphorylation of two 14-3-3-binding motifs in RAF proto-oncogene serine/threonine-protein kinase (RAF1) in response to growth factors induces high-avidity binding to dimeric 14-3-3 protein zeta/delta (YWHAZ), with pS621 being the high-affinity interaction site. This interaction locks RAF proto-oncogene serine/threonine-protein kinase (RAF1) in an inhibited conformation.	details	Curated