Switch #: SWTI000001

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.

Participants:
(1) Linker for activation of T-cells family member 1 (LAT)
(2) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)

(1) The LAT story: a tale of cooperativity, coordination, and choreography.
Balagopalan et al. Cold Spring Harb Perspect Biol (2010)

(2) Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences.
Houtman et al. Biochemistry (2004)

Other switches involving participants
Linker for activation of T-cells family member 1 (LAT) - 2 more (view)
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_SH2_STAT5 - 7 more (view)