Switch #: SWTI000025

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Hydroxylation of P531 in the VHL-binding motif of Endothelial PAS domain-containing protein 1 (EPAS1) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.

Participants:
(1) Endothelial PAS domain-containing protein 1 (EPAS1)
(2) Von Hippel-Lindau disease tumor suppressor (VHL)

(1) Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
Kondo et al. PLoS Biol. (2003)

(2) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.
Hirsilä et al. J. Biol. Chem. (2003)

Other switches involving participants
Von Hippel-Lindau disease tumor suppressor (VHL) - 5 more (view)
Endothelial PAS domain-containing protein 1 (EPAS1) - 1 more (view)

Other switches involving interfaces
DEG_ODPH_VHL_1 - 5 more (view)
von Hippel-Lindau disease tumour suppressor protein - 5 more (view)