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Switch #:
SWTI000030
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S65 in the Pin1-binding motif of Bcl-2-like protein 11 (Bcl2l11) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Bcl-2-like protein 11 (Bcl2l11)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interactions
Interaction #1 Bcl2l11 - Pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (62PPASPG67) in Bcl-2-like protein 11 (Bcl2l11)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S65 on Bcl-2-like protein 11 (Bcl2l11)) of the Bcl-2-like protein 11 (Bcl2l11) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S65 : Mitogen-activated protein kinase 3 (Mapk3), Mitogen-activated protein kinase 1 (Mapk1), Mitogen-activated protein kinase 8 (Mapk8), Mitogen-activated protein kinase 9 (Mapk9), Mitogen-activated protein kinase 10 (Mapk10), Mitogen-activated protein kinase 8 (MAPK8), Mitogen-activated protein kinase 9 (MAPK9), Mitogen-activated protein kinase 10 (MAPK10).

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) [A case from practice (219). Peripheral nerve lesions with rhabdomyolysis following heroin injection--multiple drug addictions--chronic viral-alcoholic hepatitis].
et al. Schweiz. Rundsch. Med. Prax. (1991)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) - 28 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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