About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000038
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Cellular tumor antigen p53 (TP53)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 TP53 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (312TSSSPQ317) in Cellular tumor antigen p53 (TP53)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S315 on Cellular tumor antigen p53 (TP53)) of the Cellular tumor antigen p53 (TP53) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S315 : Cyclin-dependent kinase 1 (CDK1), Cyclin-dependent kinase 2 (CDK2), Cyclin-dependent kinase 9 (CDK9), Aurora kinase A (AURKA).

Context
Switch localisation
ELM curated: nucleus, cytosol
Inferred: cytoplasm
References

(1) The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.
Zacchi et al. Nature (2002)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Cellular tumor antigen p53 (TP53) - 10 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org