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Switch #:
SWTI000038
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Cellular tumor antigen p53 (TP53)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Context
References

(1) The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.
Zacchi et al. Nature (2002)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Cellular tumor antigen p53 (TP53) - 10 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)




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