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Switch #:
SWTI000040
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Transcription factor AP-1 (JUN)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Context
References

(1) Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.
Wulf et al. EMBO J. (2001)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Transcription factor AP-1 (JUN) - 3 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)




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