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Switch #:
SWTI000046
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S431 in the Pin1-binding motif of Nuclear receptor subfamily 4 group A member 1 (NR4A1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Nuclear receptor subfamily 4 group A member 1 (NR4A1)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 NR4A1 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (428AELSPA433) in Nuclear receptor subfamily 4 group A member 1 (NR4A1)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S431 on Nuclear receptor subfamily 4 group A member 1 (NR4A1)) of the Nuclear receptor subfamily 4 group A member 1 (NR4A1) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S431 : Mitogen-activated protein kinase 1 (MAPK1).

Context
Switch localisation
ELM curated: nucleus, cytosol
Inferred: nucleoplasm
References

(1) Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis.
Chen et al. Oncogene (2011)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Nuclear receptor subfamily 4 group A member 1 (NR4A1) - 2 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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