Switch #: SWTI000051

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S518 in the Pin1-binding motif of Protein PML (PML) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Protein PML (PML)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

(1) Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.
Reineke et al. Mol. Cell. Biol. (2008)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Protein PML (PML) - 9 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)