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Switch #:
SWTI000060
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Signal transducer and activator of transcription 3 (STAT3)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 STAT3 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (724LPMSPR729) in Signal transducer and activator of transcription 3 (STAT3)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S727 on Signal transducer and activator of transcription 3 (STAT3)) of the Signal transducer and activator of transcription 3 (STAT3) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S727 : Mitogen-activated protein kinase 8 (MAPK8), Mitogen-activated protein kinase 9 (MAPK9), Protein kinase C epsilon type (PRKCE), Ribosomal protein S6 kinase alpha-3 (RPS6KA3), Serine/threonine-protein kinase mTOR (Mtor), Mitogen-activated protein kinase 14 (MAPK14), Interleukin-1 receptor-associated kinase 1 (IRAK1), Protein kinase C delta type (PRKCD).

Context
Switch localisation
ELM curated: nucleus, cytosol
Inferred: nucleoplasm
References

(1) Pin1 is required for the Ser727 phosphorylation-dependent Stat3 activity.
Lufei et al. Oncogene (2007)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Signal transducer and activator of transcription 3 (STAT3) - 1 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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