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Switch #:
SWTI000060
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Signal transducer and activator of transcription 3 (STAT3)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Context
References

(1) Pin1 is required for the Ser727 phosphorylation-dependent Stat3 activity.
Lufei et al. Oncogene (2007)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Signal transducer and activator of transcription 3 (STAT3) - 1 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)




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