Switch #: SWTI000085

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S110 in the Pin1-binding motif of Myocyte-specific enhancer factor 2C (Mef2c) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Myocyte-specific enhancer factor 2C (Mef2c)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

(1) Proline isomerase Pin1 represses terminal differentiation and myocyte enhancer factor 2C function in skeletal muscle cells.
Magli et al. J. Biol. Chem. (2010)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) - 28 more (view)
Myocyte-specific enhancer factor 2C (Mef2c) - 1 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)