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Switch #:
SWTI000099
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T146 in the Pin1-binding motif of Protein AATF (AATF) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Protein AATF (AATF)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 AATF - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (143SAKTPG148) in Protein AATF (AATF)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T146 on Protein AATF (AATF)) of the Protein AATF (AATF) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) The prolyl isomerase Pin1 affects Che-1 stability in response to apoptotic DNA damage.
De Nicola et al. J. Biol. Chem. (2007)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)




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