Switch #: SWTI000101

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of T1241 in the Pin1-binding motif of Nuclear receptor corepressor 2 (NCOR2) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Nuclear receptor corepressor 2 (NCOR2)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

(1) Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT.
Stanya et al. J. Cell Biol. (2008)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Nuclear receptor corepressor 2 (NCOR2) - 3 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)