Switch #: SWTI000105

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S137 by RAC-alpha serine/threonine-protein kinase (Akt1) in the 14-3-3-binding motif of Bcl2 antagonist of cell death (Bad) induces binding to the 14-3-3 protein beta/alpha (YWHAB) protein. This interaction inhibits the pro-apoptotic activity of Bcl2 antagonist of cell death (Bad).

Participants:
(1) Bcl2 antagonist of cell death (Bad)
(2) 14-3-3 protein beta/alpha (YWHAB)

(1) Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11.
Hsu et al. Mol. Endocrinol. (1997)

(2) Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery.
Konishi et al. Mol. Cell (2002)

Other switches involving participants
14-3-3 protein beta/alpha (YWHAB) - 8 more (view)

Other switches involving interfaces
14-3-3 protein - 38 more (view)
LIG_14-3-3_1 - 13 more (view)