Switch #: SWTI000107

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S775 by RAC-alpha serine/threonine-protein kinase (AKT1) in the 14-3-3-binding motif of Ataxin-1 (ATXN1) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.

Participants:
(1) Ataxin-1 (ATXN1)
(2) 14-3-3 protein zeta/delta (YWHAZ)

(1) Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
Chen et al. Cell (2003)

Other switches involving participants
14-3-3 protein zeta/delta (YWHAZ) - 11 more (view)
Ataxin-1 (ATXN1) - 1 more (view)

Other switches involving interfaces
14-3-3 protein - 38 more (view)
LIG_14-3-3_1 - 13 more (view)