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Switch #:
SWTI000107
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S775 by RAC-alpha serine/threonine-protein kinase (AKT1) in the 14-3-3-binding motif of Ataxin-1 (ATXN1) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.

Participants:
(1) Ataxin-1 (ATXN1)
(2) 14-3-3 protein zeta/delta (YWHAZ)

Interactions
Interaction #1 ATXN1 - YWHAZ

Interfaces
(1) LIG_14-3-3_1 motif (772RRWSAP777) in Ataxin-1 (ATXN1)
(2) 14-3-3 protein (3-236) in 14-3-3 protein zeta/delta (YWHAZ)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S775 on Ataxin-1 (ATXN1)) of the Ataxin-1 (ATXN1) LIG_14-3-3_1 motif - 14-3-3 protein zeta/delta (YWHAZ) 14-3-3 protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S775: RAC-alpha serine/threonine-protein kinase (AKT1)


Context
References

(1) Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
Chen et al. Cell (2003)

See also

Other switches involving participants
14-3-3 protein zeta/delta (YWHAZ) - 11 more (view)
Ataxin-1 (ATXN1) - 1 more (view)

Other switches involving interfaces
14-3-3 protein - 38 more (view)
LIG_14-3-3_1 - 13 more (view)




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