Switch #: SWTI000177

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y292 in the ITIM motif of Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) induces binding of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) via its SH2 domain.

Participants:
(1) Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)
(2) Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

(1) Identification of signaling motifs within human Fc gamma RIIa and Fc gamma RIIb isoforms.
Van den Herik-Oudijk et al. Blood (1995)

(2) Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation.
Fong et al. Immunol. Lett. (1996)

Other switches involving participants
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITIM - 9 more (view)