Switch #: SWTI000249

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of the leukotriene D4 ligand to the nuclear Peroxisome proliferator-activated receptor alpha (PPARA) makes the binding site for the CORNRBOX motif of Nuclear receptor corepressor 2 (NCOR2) inaccessible.

Participants:
(1) Nuclear receptor corepressor 2 (NCOR2)
(2) Peroxisome proliferator-activated receptor alpha (PPARA)

(1) Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
Xu et al. Nature (2002)

Other switches involving participants
Nuclear receptor corepressor 2 (NCOR2) - 3 more (view)
Peroxisome proliferator-activated receptor alpha (PPARA) - 1 more (view)

Other switches involving interfaces
LIG_CORNRBOX - 3 more (view)
Ligand-binding domain of nuclear hormone receptor - 21 more (view)