About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000251
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of the estrogen ligand to the nuclear Estrogen receptor (ESR1) makes the binding site for the NRBOX motif of Nuclear receptor-interacting protein 1 (NRIP1) accessible.

Participants:
(1) Nuclear receptor-interacting protein 1 (NRIP1)
(2) Estrogen receptor (ESR1)

Interactions
Context
Switch localisation
Curated: nucleus
ELM curated: nucleus
References

(1) Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.
Cavaill├Ęs et al. EMBO J. (1995)

See also

Other switches involving participants
Nuclear receptor-interacting protein 1 (NRIP1) - 9 more (view)
Estrogen receptor (ESR1) - 10 more (view)

Other switches involving interfaces
Ligand-binding domain of nuclear hormone receptor - 21 more (view)
LIG_NRBOX - 17 more (view)




Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org