Switch #: SWTI000255

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of the estrogen ligand to the nuclear Estrogen receptor (ESR1) makes the binding site for the NRBOX motif of Nuclear receptor-interacting protein 1 (NRIP1) accessible.

Participants:
(1) Nuclear receptor-interacting protein 1 (NRIP1)
(2) Estrogen receptor (ESR1)

(1) Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.
Cavaillès et al. EMBO J. (1995)

Other switches involving participants
Nuclear receptor-interacting protein 1 (NRIP1) - 9 more (view)
Estrogen receptor (ESR1) - 10 more (view)

Other switches involving interfaces
Ligand-binding domain of nuclear hormone receptor - 21 more (view)
LIG_NRBOX - 17 more (view)