Switch #: SWTI000265

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of the 15-deoxy-Delta(12,14)-prostaglandin J2 ligand to the nuclear Peroxisome proliferator-activated receptor gamma (Pparg) makes the binding site for the NRBOX motif of Nuclear receptor coactivator 6 (Ncoa6) accessible.

Participants:
(1) Nuclear receptor coactivator 6 (Ncoa6)
(2) Peroxisome proliferator-activated receptor gamma (Pparg)

(1) Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.
Kim et al. Mol. Cell. Biol. (2003)

(2) Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR.
Zhu et al. J. Biol. Chem. (2000)

Other switches involving interfaces
Ligand-binding domain of nuclear hormone receptor - 21 more (view)
LIG_NRBOX - 17 more (view)