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Switch #:
SWTI000301
Switch type:
Pre-assembly
Switch subtype:
Composite binding site formation

Description:
Binding of Genome polyprotein to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand.

Participants:
(1) Integrin alpha-V (ITGAV)
(2) Integrin beta-3 (ITGB3)
(3) Genome polyprotein

Interactions
This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step
2Interaction #2 - Interaction #1 ITGAV - ITGB3

Requires Interaction #1 ITGAV - ITGB3

Interfaces
(3) LIG_RGD motif (869RGD871) in Genome polyprotein
(4) Interaction #1 ITGAV - ITGB3
Context
References

(1) Antibodies to the vitronectin receptor (integrin alpha V beta 3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells.
Berinstein et al. J. Virol. (1995)

See also

Other switches involving participants
Integrin beta-3 (ITGB3) - 15 more (view)
Integrin alpha-V (ITGAV) - 8 more (view)

Other switches involving interfaces
FG-GAP repeat - 13 more (view)
Integrin, beta chain - 13 more (view)
LIG_RGD - 12 more (view)




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