Switch #: SWTI000330

Switch type: Specificity

Switch subtype: Domain hiding

Description:
Binding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).

Participants:
(1) Cyclin-dependent kinase inhibitor 1B (CDKN1B)
(2) Cyclin-A2 (CCNA2)
(3) Cell division control protein 6 homolog (CDC6)

(1) Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21.
Wang et al. Nat. Chem. Biol. (2011)

Other switches involving participants
Cyclin-dependent kinase inhibitor 1B (CDKN1B) - 4 more (view)
Cyclin-A2 (CCNA2) - 1 more (view)

Other switches involving interfaces
DOC_CYCLIN_1 - 3 more (view)
Cyclin, N-terminal domain - 3 more (view)