Switch #: SWTI000350

Switch type: Avidity-sensing

Description:
Orexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).

Participants:
(1) Orexin receptor type 1 (HCRTR1)
(2) Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

(1) Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis.
El Firar et al. FASEB J. (2009)

Other switches involving participants
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) - 9 more (view)
Orexin receptor type 1 (HCRTR1) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITIM - 9 more (view)
LIG_TYR_ITSM - 4 more (view)