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Switch #:
SWTI000374
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK2 (JAK2) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Tyrosine-protein kinase JAK2 (JAK2)

Interactions
Interaction #1 EGFR - JAK2

Interfaces
(1) ELM:LIG_SH2_IE motif (1008DDVVDADEYLIPQQGFF1024) in Epidermal growth factor receptor (EGFR)
(2) SH2 domain (400-481) in Tyrosine-protein kinase JAK2 (JAK2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1016 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_SH2_IE motif - Tyrosine-protein kinase JAK2 (JAK2) SH2 domain interaction


Context
References

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)

See also

Other switches involving participants
Epidermal growth factor receptor (EGFR) - 14 more (view)
Tyrosine-protein kinase JAK2 (JAK2) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IE - 11 more (view)




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