Switch #: SWTI000374

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK2 (JAK2) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Tyrosine-protein kinase JAK2 (JAK2)

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)

Other switches involving participants
Epidermal growth factor receptor (EGFR) - 14 more (view)
Tyrosine-protein kinase JAK2 (JAK2) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IE - 11 more (view)