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Switch #:
SWTI000380
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1023 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-2 (ERBB2) induces binding to the Tyrosine-protein kinase JAK2 (JAK2) protein.

Participants:
(1) Receptor tyrosine-protein kinase erbB-2 (ERBB2)
(2) Tyrosine-protein kinase JAK2 (JAK2)

Interactions
Interaction #1 ERBB2 - JAK2

Interfaces
(1) ELM:LIG_SH2_IE motif (1015GDLVDAEEYLVPQQGFF1031) in Receptor tyrosine-protein kinase erbB-2 (ERBB2)
(2) SH2 domain (400-481) in Tyrosine-protein kinase JAK2 (JAK2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1023 on Receptor tyrosine-protein kinase erbB-2 (ERBB2)) of the Receptor tyrosine-protein kinase erbB-2 (ERBB2) LIG_SH2_IE motif - Tyrosine-protein kinase JAK2 (JAK2) SH2 domain interaction


Context
References

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)

See also

Other switches involving participants
Tyrosine-protein kinase JAK2 (JAK2) - 4 more (view)
Receptor tyrosine-protein kinase erbB-2 (ERBB2) - 5 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IE - 11 more (view)




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