Switch #: SWTI000380

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1023 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-2 (ERBB2) induces binding to the Tyrosine-protein kinase JAK2 (JAK2) protein.

Participants:
(1) Receptor tyrosine-protein kinase erbB-2 (ERBB2)
(2) Tyrosine-protein kinase JAK2 (JAK2)

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)

Other switches involving participants
Tyrosine-protein kinase JAK2 (JAK2) - 4 more (view)
Receptor tyrosine-protein kinase erbB-2 (ERBB2) - 5 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IE - 11 more (view)