Switch #: SWTI000403

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y504 in the SH2-binding motif of Erythropoietin receptor (EPOR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.

Participants:
(1) Erythropoietin receptor (EPOR)
(2) Signal transducer and activator of transcription 5B (STAT5B)

(1) A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation.
Barber et al. Blood (2001)

Other switches involving participants
Signal transducer and activator of transcription 5B (STAT5B) - 5 more (view)
Erythropoietin receptor (EPOR) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_III - 15 more (view)