Switch #: SWTI000422

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y349 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.

Participants:
(1) Fibroblast growth factor receptor substrate 2 (FRS2)
(2) Growth factor receptor-bound protein 2 (GRB2)

(1) Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.
Zhang et al. Mol. Endocrinol. (2008)

Other switches involving participants
Growth factor receptor-bound protein 2 (GRB2) - 12 more (view)
Fibroblast growth factor receptor substrate 2 (FRS2) - 5 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IC - 12 more (view)