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Switch #:
Switch type:
Switch subtype:
Physicochemical compatibility

Phosphorylation of Y757 in the SH2-binding motif of Interleukin-6 receptor subunit beta (Il6st) induces binding to the Suppressor of cytokine signaling 3 (Socs3) protein.

(1) Interleukin-6 receptor subunit beta (Il6st)
(2) Suppressor of cytokine signaling 3 (Socs3)

Interaction #1 Il6st - Socs3

(1) ELM:LIG_SH2_IIA motif (750STASTVEYSTVVHSG764) in Interleukin-6 receptor subunit beta (Il6st)
(2) SH2 domain (46-127) in Suppressor of cytokine signaling 3 (Socs3)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y757 on Interleukin-6 receptor subunit beta (Il6st)) of the Interleukin-6 receptor subunit beta (Il6st) LIG_SH2_IIA motif - Suppressor of cytokine signaling 3 (Socs3) SH2 domain interaction

Additional Information
Structural information: 2BBU

(1) The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.
Babon et al. Mol. Cell (2006)

See also

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)

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