Switch #: SWTI000444

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y757 in the SH2-binding motif of Interleukin-6 receptor subunit beta (Il6st) induces binding to the Suppressor of cytokine signaling 3 (Socs3) protein.

Participants:
(1) Interleukin-6 receptor subunit beta (Il6st)
(2) Suppressor of cytokine signaling 3 (Socs3)

(1) The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.
Babon et al. Mol. Cell (2006)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)