Switch #: SWTI000446

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.

Participants:
(1) Tyrosine-protein kinase ZAP-70 (ZAP70)
(2) E3 ubiquitin-protein ligase CBL-B (CBLB)

(1) A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.
Zhang et al. Curr. Biol. (1999)

Other switches involving participants
Tyrosine-protein kinase ZAP-70 (ZAP70) - 5 more (view)
E3 ubiquitin-protein ligase CBL-B (CBLB) - 1 more (view)

Other switches involving interfaces
IPR:IPR000980 - 9 more (view)
ELM:LIG_SH2_IIC - 1 more (view)