Switch #: SWTI000448

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y604 in the SH2-binding motif of Ephrin type-B receptor 2 (Ephb2) induces binding to the Adapter molecule crk (CRK) protein.

Participants:
(1) Ephrin type-B receptor 2 (Ephb2)
(2) Adapter molecule crk (CRK)

(1) Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses.
Zisch et al. Oncogene (2000)

Other switches involving participants
Adapter molecule crk (CRK) - 7 more (view)
Ephrin type-B receptor 2 (Ephb2) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)