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Physicochemical compatibility

Phosphorylation of Y604 in the SH2-binding motif of Ephrin type-B receptor 2 (Ephb2) induces binding to the Adapter molecule crk (CRK) protein.

(1) Ephrin type-B receptor 2 (Ephb2)
(2) Adapter molecule crk (CRK)

Interaction #1 Ephb2 - CRK

(1) ELM:LIG_SH2_IB motif (601MKIYIDPFTY610) in Ephrin type-B receptor 2 (Ephb2)
(2) SH2 domain (13-104) in Adapter molecule crk (CRK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y604 on Ephrin type-B receptor 2 (Ephb2)) of the Ephrin type-B receptor 2 (Ephb2) LIG_SH2_IB motif - Adapter molecule crk (CRK) SH2 domain interaction


(1) Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses.
Zisch et al. Oncogene (2000)

See also

Other switches involving participants
Adapter molecule crk (CRK) - 7 more (view)
Ephrin type-B receptor 2 (Ephb2) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)

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