Switch #: SWTI000481

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the NRBOX motif of Isoform TXNRD1_v2 of Thioredoxin reductase 1, cytoplasmic (TXNRD1), abrogating binding to Estrogen receptor (ESR1). Unlike splice variants without the NRBOX motif, TrxR1b (also known as Isoform TXNRD1_v2 of Thioredoxin reductase 1, cytoplasmic (TXNRD1)) is identified within the nucleus. TrxR1b enhanced the transcriptional activity of the estrogen receptors ESR1 and ESR2, possibly by providing a reduced environment in the immediate vicinity of the ERs.

Participants:
(1) Isoform TXNRD1_v2 of Thioredoxin reductase 1, cytoplasmic (TXNRD1)
(2) Estrogen receptor (ESR1)

(1) An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.
Damdimopoulos et al. J. Biol. Chem. (2004)

Other switches involving participants
Estrogen receptor (ESR1) - 10 more (view)
Isoform TXNRD1_v2 of Thioredoxin reductase 1, cytoplasmic (TXNRD1) - 1 more (view)

Other switches involving interfaces
Ligand-binding domain of nuclear hormone receptor - 21 more (view)
LIG_NRBOX - 17 more (view)