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Alternative splicing removes the PDZ-binding motif of Plasma membrane calcium-transporting ATPase 4 (ATP2B4), abrogating binding to Nitric oxide synthase, brain (NOS1). PMCA4b acts as a negative regulator of Nitric oxide synthase, brain (NOS1), reducing production of nitric oxide in heart tissue. This negative regulation was not dependent on a conformational change due to binding of the PDZ ligand, but on Ca2+ depletion in close proximity of the enzyme. Nitric oxide production by NOS1 is known to be important in the regulation of excitation-contraction (EC) coupling and subsequently contractility.

(1) Plasma membrane calcium-transporting ATPase 4 (ATP2B4)
(2) Nitric oxide synthase, brain (NOS1)


(1) The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I.
Schuh et al. J. Cell Biol. (2001)

See also

Other switches involving participants
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) - 5 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)

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