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Switch #:
SWTI000503
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).

Participants:
(1) Paxillin (PXN)
(2) Adapter molecule crk (CRK)

Interactions
Interaction #1 PXN - CRK

Interfaces
(1) ELM:LIG_SH2_IB motif (118YSFP121) in Paxillin (PXN)
(2) Focal adhesion targeting region (13-118) in Adapter molecule crk (CRK)

Interaction Regulation
Alternative splicing Abrogation of the Paxillin (PXN) LIG_SH2_IB motif - Adapter molecule crk (CRK) Focal adhesion targeting region interaction

Context

Switch pathways
Inferred: Chemokine signaling pathway, Regulation of actin cytoskeleton, Focal adhesion
References

(1) Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta.
Tumbarello et al. J. Cell. Sci. (2005)

(2) Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells.
Petit et al. J. Cell Biol. (2000)

See also

Other switches involving participants
Adapter molecule crk (CRK) - 7 more (view)
Paxillin (PXN) - 4 more (view)

Other switches involving interfaces
ELM:LIG_SH2_IB - 13 more (view)
Focal adhesion targeting region - 4 more (view)


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