Switch #: SWTI000519

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the deubiquitinating enzyme USP7-binding motif of Cellular tumor antigen p53 (TP53), abrogating binding to Ubiquitin carboxyl-terminal hydrolase 7 (USP7).

Participants:
(1) Cellular tumor antigen p53 (TP53)
(2) Ubiquitin carboxyl-terminal hydrolase 7 (USP7)

(1) p53 isoforms can regulate p53 transcriptional activity.
Bourdon et al. Genes Dev. (2005)

Other switches involving participants
Cellular tumor antigen p53 (TP53) - 10 more (view)
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) - 2 more (view)

Other switches involving interfaces
DOC_USP7_1 - 2 more (view)
Ubiquitin-specific protease 7 - 1 more (view)