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Switch #:
SWTI000566
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the nuclear export signal (NES) motif of Mothers against decapentaplegic homolog 4 (SMAD4), thereby inhibiting binding to Exportin-1 (XPO1) and export from the nucleus. A splice variant lacking the NES does not shuttle back and forth between nucleus and cytosol. At present, this particular splice variant is not annotated in UniProtKB.

Participants:
(1) Mothers against decapentaplegic homolog 4 (SMAD4)
(2) Exportin-1 (XPO1)

Interactions
Interaction #1 SMAD4 - XPO1

Interfaces
(1) ELM:TRG_NES_CRM1_2 motif (142DLSGLTLQ149) in Mothers against decapentaplegic homolog 4 (SMAD4)
(2) Exportin 1-like protein (123-268) in Exportin-1 (XPO1)

Interaction Regulation
Alternative splicing Abrogation of the Mothers against decapentaplegic homolog 4 (SMAD4) TRG_NES_CRM1_2 motif - Exportin-1 (XPO1) Exportin 1-like protein interaction

Context
Switch localisation
Curated: nucleus
References

(1) Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.
Pierreux et al. Mol. Cell. Biol. (2000)

See also

Other switches involving participants
Exportin-1 (XPO1) - 7 more (view)

Other switches involving interfaces
Exportin 1-like protein - 9 more (view)
ELM:TRG_NES_CRM1_2 - 3 more (view)




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