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Switch #:
SWTI000588
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Isoform 4 of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1), abrogating binding to Disks large homolog 4 (DLG4). Binding of the PDZ domain of DLG4 suppresses an ER-retention motif in GRIN1, promoting its cell surface expression in a splice variant-specific manner.

Participants:
(1) Isoform 4 of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1)
(2) Disks large homolog 4 (DLG4)

Interactions
Context
References

(1) PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants.
Standley et al. Neuron (2000)

See also

Other switches involving participants
Disks large homolog 4 (DLG4) - 7 more (view)
Isoform 4 of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1) - 5 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)




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