Description: Alternative splicing removes the PDZ-binding motif of Isoform 7.5kb of Synaptojanin-2 (Synj2), abrogating binding to Synaptojanin-2-binding protein (Synj2bp). Isoform 7.5kb of Synaptojanin-2 (Synj2) (Synaptojanin 2A) is recruited to mitochondria through the interaction with the PDZ domain of the mitochondrial outer membrane protein Synj2bp.
Participants: (1) Isoform 7.5kb of Synaptojanin-2 (Synj2) (2) Synaptojanin-2-binding protein (Synj2bp)
(1) Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals.Nemoto et al. J. Biol. Chem. (2001) (2) Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein.Nemoto et al. EMBO J. (1999)
Other switches involving interfacesPDZ domain (Also known as DHR or GLGF) - 45 more (view)LIG_PDZ_Class_1 - 41 more (view)
