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Physicochemical compatibility

Phosphorylation of Y232 in the SH2-binding motif of Disabled homolog 1 (Dab1) induces binding to Cytoplasmic protein NCK2 (NCK2).

(1) Disabled homolog 1 (Dab1)
(2) Cytoplasmic protein NCK2 (NCK2)

Interaction #1 Dab1 - NCK2

(1) ELM:LIG_SH2_IA motif (232YDVP235) in Disabled homolog 1 (Dab1)
(2) SH2 domain (285-323) in Cytoplasmic protein NCK2 (NCK2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y232 on Disabled homolog 1 (Dab1)) of the Disabled homolog 1 (Dab1) LIG_SH2_IA motif - Cytoplasmic protein NCK2 (NCK2) SH2 domain interaction


(1) Splice-mediated motif switching regulates Disabled-1 phosphorylation and SH2 domain interactions.
Gao et al. (2012)

(2) Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons.
Ballif et al. Curr. Biol. (2004)

(3) Interaction between Dab1 and CrkII is promoted by Reelin signaling.
Chen et al. J. Cell. Sci. (2004)

(4) Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.
Huang et al. Biochem. Biophys. Res. Commun. (2004)

See also

Other switches involving participants
Cytoplasmic protein NCK2 (NCK2) - 6 more (view)
Disabled homolog 1 (Dab1) - 10 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IA - 16 more (view)

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