Switch #: SWTI000639

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Sialic acid-binding Ig-like lectin 12 (Siglec12), abrogating binding to Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6).

Participants:
(1) Sialic acid-binding Ig-like lectin 12 (Siglec12)
(2) Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6)

(1) Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2.
Ulyanova et al. J. Biol. Chem. (2001)

Other switches involving participants
Sialic acid-binding Ig-like lectin 12 (Siglec12) - 3 more (view)
Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITIM - 9 more (view)