Switch #: SWTI000642

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing partially removes the SH2-binding motif of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partially inhibiting binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1).

Participants:
(1) Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d)
(2) Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1)

(1) Structure, function, and biology of SHIP proteins.
Rohrschneider et al. Genes Dev. (2000)

Other switches involving participants
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d) - 1 more (view)
Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)