Switch #: SWTI000645

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Binding of the BIR domain-binding motif of Caspase-7 (CASP7) to the BIR domains of Baculoviral IAP repeat-containing protein 2 (BIRC2) requires cleavage of Caspase-7 (CASP7) at D23, since this results in a functional neo N-terminal motif. BIR domains are found in Inhibitor of Apoptosis Proteins (IAPs) that suppress the activity of activated caspases, either by directly inhibiting caspase catalytic activity, or by targeting caspases for degradation by ubiquitin modification.

Participants:
(1) Caspase-7 (CASP7)
(2) Baculoviral IAP repeat-containing protein 2 (BIRC2)

(1) The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.
Choi et al. J. Biol. Chem. (2009)

Other switches involving participants
Baculoviral IAP repeat-containing protein 2 (BIRC2) - 3 more (view)
Caspase-7 (CASP7) - 2 more (view)

Other switches involving interfaces
Inhibitor of Apoptosis domain - 8 more (view)
LIG_BIR_III_2 - 4 more (view)