Interaction #1 Akap12 - Ccnd1
(1) DOC_CYCLIN_1 motif (501KKLF504) in A-kinase anchor protein 12 (Akap12)
(2) Cyclin, N-terminal domain (26-153) in G1/S-specific cyclin-D1 (Ccnd1)
PTM-dependent Abrogation (Phosphorylation of S507 on A-kinase anchor protein 12 (Akap12)) of the A-kinase anchor protein 12 (Akap12) DOC_CYCLIN_1 motif - G1/S-specific cyclin-D1 (Ccnd1) Cyclin, N-terminal domain interaction
Regulatory Enzymes for switch
Modifying enzymes for residue: S507: PKC subfamily
(1) SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1)-->S progression by controlling the expression and cellular compartmentalization of cyclin D.