Switches.ELM

Switch #:

SWTI000683

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S507 adjacent to the cyclin-binding motif of A-kinase anchor protein 12 (Akap12) by PKC subfamily blocks binding to the G1/S-specific cyclin-D1 (Ccnd1). As a result, the function of A-kinase anchor protein 12 (Akap12) as a scaffold is inhibited and G1/S-specific cyclin-D1 (Ccnd1) is translocated to the nucleus where it regulates progression of the cell cycle from G1 to S phase.

Participants:
(1) A-kinase anchor protein 12 (Akap12)
(2) G1/S-specific cyclin-D1 (Ccnd1)

Interactions

Interaction #1 Akap12 - Ccnd1

Interfaces
(1) DOC_CYCLIN_1 motif (₅₀₁KKLF₅₀₄) in A-kinase anchor protein 12 (Akap12)
(2) Cyclin, N-terminal domain_(26-153) in G1/S-specific cyclin-D1 (Ccnd1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S₅₀₇ on A-kinase anchor protein 12 (Akap12)) of the A-kinase anchor protein 12 (Akap12) DOC_CYCLIN_1 motif - G1/S-specific cyclin-D1 (Ccnd1) Cyclin, N-terminal domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₅₀₇: PKC subfamily

Context

References

(1) SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1)-->S progression by controlling the expression and cellular compartmentalization of cyclin D.
Lin et al. Mol. Cell. Biol. (2000)