Switch #: SWTI000723

Switch type: Pre-assembly

Switch subtype: Composite binding site formation

Description:
Binding of to Coi1, an F-box substrate recognition subunit of the SCF E3 ubiquitin ligase, depends on binding of the plant hormone jasmonate to COI1, as this pre-assembled complex provides a composite binding site for the degron motif in the JAZ protein. Subsequent ubiquitylation of the JAZ protein by the SCF targets this transcriptional repressor for proteasomal degradation, a pre-requisite for the transcriptional response to jasmonate.

Participants:
(1)
(2) Coi1
(3)

This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step

1Interaction #1 - Coi1

Interfaces
(1) N-[(3R,7S)-(+)-7-iso-Jasmonoyl]-(S)-isoleucine in
(2) Coi1

2Interaction #2 - Interaction #1 - Coi1

Requires Interaction #1 - Coi1

Interfaces
(3) DEG_SCF_COI1_1 motif (₂₅₁QARKASLARFLEKRKERV₂₆₈) in
(4) Interaction #1 - Coi1

(1) COI1 is a critical component of a receptor for jasmonate and the bacterial virulence factor coronatine.
Katsir et al. Proc. Natl. Acad. Sci. U.S.A. (2008)

Other switches involving participants
- 5 more (view)
Coi1 - 1 more (view)

Other switches involving interfaces
Leucine-rich repeat (LRR) - 11 more (view)
N-[(3R,7S)-(+)-7-iso-Jasmonoyl]-(S)-isoleucine - 5 more (view)
DEG_SCF_COI1_1 - 5 more (view)