Please send any suggestions/comments to: switches@elm.eu.org
| Proto-oncogene tyrosine-protein kinase LCK (Mus) | Tyrosine-protein kinase Fyn (Mus) | Tyrosine-protein kinase JAK2 |
| Tyrosine-protein kinase Lck |
| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Proto-oncogene tyrosine-protein kinase LCK - LCK - Mus musculus | ||||||||
| LIG_SH2_STAT5 | CTLA4_MOUSE | 201 | 204 | Specificity | Altered binding specificity | Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4. | Inferred | |
Tyrosine-protein kinase Fyn - FYN - Mus musculus | ||||||||
| LIG_SH2_STAT5 | CTLA4_MOUSE | 201 | 204 | Specificity | Altered binding specificity | Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4. | Inferred | |
Tyrosine-protein kinase JAK2 - JAK2 - Homo sapiens | ||||||||
| LIG_SH2_STAT5 | CTLA4_MOUSE | 201 | 204 | Specificity | Altered binding specificity | Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4. | Inferred | |
| LIG_SH2_STAT5 | CTLA4_MOUSE | 201 | 204 | Specificity | Altered binding specificity | Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4. | Inferred | |
Tyrosine-protein kinase Lck - LCK - Homo sapiens | ||||||||
| LIG_SH2_STAT5 | CTLA4_MOUSE | 201 | 204 | Specificity | Altered binding specificity | Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4. | Inferred | |