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| RAC-alpha serine/threonine-protein kinase | cAMP-dependent protein kinase catalytic subunit alpha |
| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
RAC-alpha serine/threonine-protein kinase - AKT1 - Homo sapiens | ||||||||
| LIG_14-3-3_1 | ATX1_HUMAN | 772 | 777 | Binary | Physicochemical compatibility | Phosphorylation of S775 by RAC-alpha serine/threonine-protein kinase (AKT1) in the 14-3-3-binding motif of Ataxin-1 (ATXN1) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. | Curated | |
| LIG_ULM_U2AF65_1 | ATX1_HUMAN | 770 | 775 | Specificity | Altered binding specificity | Phosphorylation of S775 switches binding specificity of Ataxin-1 (ATXN1) from the splicing factor Splicing factor U2AF 65 kDa subunit (U2AF2) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)). While association with the spliceosome protects ATXN1 from self-association, its phosphorylation-dependent recruitment to 14-3-3 proteins (e.g. YWHAZ) might result in aggregation. | Inferred | |
| LIG_14-3-3_1 | ATX1_HUMAN | 772 | 777 | Specificity | Altered binding specificity | Phosphorylation of S775 switches binding specificity of Ataxin-1 (ATXN1) from the splicing factor Splicing factor U2AF 65 kDa subunit (U2AF2) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)). While association with the spliceosome protects ATXN1 from self-association, its phosphorylation-dependent recruitment to 14-3-3 proteins (e.g. YWHAZ) might result in aggregation. | Inferred | |
cAMP-dependent protein kinase catalytic subunit alpha - PRKACA - Homo sapiens | ||||||||
| LIG_14-3-3_1 | ATX1_HUMAN | 772 | 777 | Binary | Physicochemical compatibility | Phosphorylation of S775 by RAC-alpha serine/threonine-protein kinase (AKT1) in the 14-3-3-binding motif of Ataxin-1 (ATXN1) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. | Inferred | |
| LIG_ULM_U2AF65_1 | ATX1_HUMAN | 770 | 775 | Specificity | Altered binding specificity | Phosphorylation of S775 switches binding specificity of Ataxin-1 (ATXN1) from the splicing factor Splicing factor U2AF 65 kDa subunit (U2AF2) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)). While association with the spliceosome protects ATXN1 from self-association, its phosphorylation-dependent recruitment to 14-3-3 proteins (e.g. YWHAZ) might result in aggregation. | Inferred | |
| LIG_14-3-3_1 | ATX1_HUMAN | 772 | 777 | Specificity | Altered binding specificity | Phosphorylation of S775 switches binding specificity of Ataxin-1 (ATXN1) from the splicing factor Splicing factor U2AF 65 kDa subunit (U2AF2) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)). While association with the spliceosome protects ATXN1 from self-association, its phosphorylation-dependent recruitment to 14-3-3 proteins (e.g. YWHAZ) might result in aggregation. | Inferred | |