switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:Q99704 (8 hits) x

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Curated inferred

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Epidermal growth factor receptor

Proto-oncogene tyrosine-protein kinase Src

Motif

Protein

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Evidence

Epidermal growth factor receptor - EGFR - Homo sapiens
LIG_PTB_Phospho_1	EGFR_HUMAN	1104	1110	Binary	Physicochemical compatibility	Phosphorylation of Y1110 in the PTB-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Docking protein 1 (DOK1) protein.	details	Inferred
LIG_PTB_Phospho_1	EGFR_HUMAN	1104	1110	Binary	Physicochemical compatibility	Phosphorylation of Y1110 in the PTB-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Docking protein 1 (DOK1) protein.	details	Inferred
Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_PTB_Phospho_1	ITB3_HUMAN	767	773	Binary	Physicochemical compatibility	Phosphorylation of Y773 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the Docking protein 1 (DOK1) protein.	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	767	773	Binary	Physicochemical compatibility	Phosphorylation of Y773 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the Docking protein 1 (DOK1) protein.	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	767	773	Binary	Physicochemical compatibility	Phosphorylation of Y773 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the Docking protein 1 (DOK1) protein.	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	767	773	Specificity	Altered binding specificity	Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation.	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	767	773	Specificity	Altered binding specificity	Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation.	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	767	773	Specificity	Altered binding specificity	Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation.	details	Inferred