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Physicochemical compatibility

Phosphorylation of Y773 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the Docking protein 1 (DOK1) protein.

(1) Integrin beta-3 (ITGB3)
(2) Docking protein 1 (DOK1)

Interaction #1 ITGB3 - DOK1

(1) LIG_PTB_Phospho_1 motif (767TANNPLY773) in Integrin beta-3 (ITGB3)
(2) PTB domain (IRS-1 type) (151-254) in Docking protein 1 (DOK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y773 on Integrin beta-3 (ITGB3)) of the Integrin beta-3 (ITGB3) LIG_PTB_Phospho_1 motif - Docking protein 1 (DOK1) PTB domain (IRS-1 type) interaction

Additional Information
Structural information: 2L1C

(1) Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.
Calderwood et al. Proc. Natl. Acad. Sci. U.S.A. (2003)

(2) Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain.
Deshmukh et al. J. Biol. Chem. (2010)

(3) An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.
Oxley et al. J. Biol. Chem. (2008)

See also

Other switches involving participants
Docking protein 1 (DOK1) - 4 more (view)
Integrin beta-3 (ITGB3) - 15 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
PTB domain (IRS-1 type) - 12 more (view)

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