Interaction #1 INSR - SHC1
(1) LIG_PTB_Phospho_1 motif (993ASSNPEY999) in Insulin receptor (INSR)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)
PTM-dependent Induction (Phosphorylation of Y999 on Insulin receptor (INSR)) of the Insulin receptor (INSR) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y999 : Insulin receptor (INSR).
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
(1) Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphorylation by insulin in vivo.
Other switches involving participants