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Switch #:
SWTI000138
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) Insulin receptor (INSR)
(2) SHC-transforming protein 1 (SHC1)

Interactions
Interaction #1 INSR - SHC1

Interfaces
(1) LIG_PTB_Phospho_1 motif (993ASSNPEY999) in Insulin receptor (INSR)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y999 on Insulin receptor (INSR)) of the Insulin receptor (INSR) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y999 : Insulin receptor (INSR).

Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
Inferred: cytosol, nucleus, endosome membrane


Switch pathways
Inferred: Insulin signaling pathway
References

(1) Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphorylation by insulin in vivo.
Isakoff et al. J. Biol. Chem. (1996)

See also

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)
Insulin receptor (INSR) - 1 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)


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